Antipsychotic

Olanzapine 5 mg, n30

International Nonproprietary Name (INN): olanzapine.

Pharmaceutical group: Antipsychotic (neuroleptic).

Presentation:

Tablets 5 mg, 10 mg n30.

Available with prescription

Question?

THERE ARE CONTRAINDICATIONS. CAREFULLY READ THE INSTRUCTIONS FOR USE, OR OBTAIN A SPECIALIST ADVICE

Olanapine is a preparation, which is usually prescribed by specialists in the psychiatry or neurology. Main indications include: schizophrenia, maniac episodes, schizoaffective or bipolar disorders, depression (in combination with fluoxetine). The course of treatment with Olanzapine is usually prolonged. This medicine eliminates productive and negative symptoms of these diseases. In comparison with haloperidol, olanzapine shows better remission period (a state of absence of the main disease’s exacerbations) and improves scores in Montgomery–Åsberg Depression Rating Scale.

Olanzapine, a thienobenzodiazepine, is an antipsychotic agent that demonstrates a broad pharmacologic profile across a number of receptor systems. Olanzapine displays high receptor affinity binding in vitro at dopamine D2, D3, D4, 5-HT2A/C, 5-HT3, 5-HT6, muscarinic M1-M5, adrenergic α1, and histamine H1 receptor subtypes, while displaying a lower affinity at dopamine D1 and D5 receptor subtypes. In a behavioural paradigm predictive of antipsychotic activity, olanzapine reduced conditioned avoidance response in rats at doses lower than 4 times those required to produce catalepsy. In a single dose (10 mg) PET study in healthy subjects, olanzapine produced higher 5-HT2A than dopamine D2 receptor occupancy. The percent of D2 occupancy was less than the threshold value predictive of extrapyramidal events. Before prescribing this remedy, be sure to read carefully a specialist’s leaflet.

This preparation should be taken orally, usually once a day. It may be taken independently on meal as far as food doesn’t influence upon an absorbability of the drug. The dosage and treatment’s tactics depends on specific features of a concrete patient and/or indication. The dosage usually varies from 5 mg till 20 mg per day. Olanzapine is commonly administrated as the only psychotropic agent (monotherapy), but in some indications it may be combined with preparations of lithium or valproic acid; in the case of therapeutically resistant depression it can be used together with fluoxetine.

More information about Olanzapine’s medical usage you can find in the approved leaflet (in Russian language only), which is included in each carton box with the product.