Hypotensive

Amlodipine 5 mg, n30

International Nonproprietary Name (INN): Amlodipine

Pharmaceutic group: Hypotensive

Presentation:

Tablets 5 mg n30 or 10 mg n30.

Available with prescription

Question?

THERE ARE CONTRAINDICATIONS. CAREFULLY READ THE INSTRUCTIONS FOR USE, OR OBTAIN A SPECIALIST ADVICE

Amlodipine is in a group of drugs called calcium channel blockers. Amlodipine relaxes (widens) blood vessels and improves blood flow. Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or calcium slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.

Amlodipine is used to treat high blood pressure (hypertension) or chest pain (angina) and other conditions caused by coronary artery disease. This medication is for use mainly in adults (above 18 years). Amlodipine may also be used for other purposes not listed in this medication guide.

The metabolism and excretion of Amlodipine have been studied in healthy volunteers following oral administration of 14C-labelled drug. Amlodipine is well absorbed by the oral route with a mean oral bioavailability of approximately 60%. Renal elimination is the major route of excretion with about 60% of an administered dose recovered in urine, largely as inactive pyridine metabolites. Amlodipine concentrations in plasma declined with a mean half-life of 33 h, while elimination of total drug-related material from plasma was slower.

Important information about amlodipine

Before taking amlodipine, tell your doctor if you have congestive heart failure or liver disease.

Drinking alcohol can further lower your blood pressure and may increase certain side effects of amlodipine.

If you are being treated for high blood pressure, keep using amlodipine even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life.

Amlodipine is only part of a complete program of treatment that may also include diet, exercise, weight control, and other medications. Follow your diet, medication, and exercise routines very closely.

Tell your doctor about all other heart or blood pressure medications you are taking.

Your chest pain may become worse when you first start taking amlodipine or when your dose is increased. Call your doctor if your chest pain is severe or ongoing.

You should not take this medication if you are allergic to amlodipine.

To make sure you can safely take amlodipine, tell your doctor if you have any of these other conditions:

•a heart valve problem called aortic stenosis;

•congestive heart failure; or

•liver disease.

If you are also taking a beta-blocker drug (such as Betapace, Blocadren, Corgard, Coreg, Inderal, InnoPran, Lopressor, Normodyne, Tenoretic, Tenormin, Toprol, Trandate, Zebeta, and others) do not suddenly stop using the beta-blocker without first talking to your doctor. You may need to use less and less before you stop the medication completely. Stopping a beta-blocker too quickly can cause serious heart problems that will not be prevented by amlodipine.

FDA pregnancy category C. It is not known whether amlodipine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. It is not known whether amlodipine passes into breast milk or if it could harm a nursing baby. You should not breast-feed while you are taking amlodipine.