Vinpocetine 5 mg, n50

International Nonproprietary Name (INN):Vinpocetine

Pharmaceutic group: Vascular


Tablets 5 mg n20, n30 or n50.

Available with prescription



Vinpocetine (brand names: Cavinton, Intelectol; chemical name: ethyl apovincaminate) is a semisynthetic derivative alkaloid of vincamine (sometimes described as "a synthetic ethyl ester of apovincamine"), an extract from the periwinkle plant (Vinca minor).

Vinpocetine is reported to have cerebral blood-flow enhancing and neuroprotective effects, and is used as a drug in Eastern Europe for the treatment of cerebrovascular disorders and age-related memory impairment.

Vinpocetine is widely marketed as a supplement for vasodilation and as a nootropic for the improvement of memory. In other words, Vinpocetine may help support brain functions such as concentration and memory by activating cerebral metabolism. A small subset of users report uncomfortable, adverse reactions to vinpocetine. A low initial dosage is ordinarily recommended.

Vinpocetine has been shown to selectively inhibit voltage-sensitive Na+ channels, resulting in a dose-dependent decrease in evoked extracellular Ca+ ions in striatal nerve endings. The Na+ channel inhibiting properties of vinpocetine are thought to contribute to a general neuroprotective effect through blockade of excitotoxicity and attenuation of neuronal damage induced by cerebral ischemia/reperfusion. It is not known exactly how vinpocetine works, but it seems to have various effects on the brain including increased blood flow.

The scientific literature contains numerous studies and investigations on the pharmacological and biochemical actions of vinpocetine. The various mechanism of actions include:

1) effects on brain circulation and oxygen utilization without changes in systemic circulation;

2) increased tolerance of the brain to vascular hypoxia and ischemia;

3) anticonvulsant activity;

4) phosphodiesterase-1 inhibition; and

5) lowering of blood viscosity and inhibition of aggregation of thrombocytes.

Vinpocetine appears to be safe for most people. It can cause some side effects including stomach pain, nausea, sleep disturbances, headache, dizziness, nervousness, and flushing of the face.

CONTRAINDICATIONS: Do not use vinpocetine if:

• You are pregnant or breast-feeding.

• You have a blood-clotting disorder.

• You are scheduled for surgery in the next two weeks. Vinpocetine might increase the risk of bleeding.

• You are a patient with severe, general, cerebral hypertensive crises, or in elderly or senile patients with acute cardio-cerebral or cerebro-cardiac syndrome, postinfarction cardiosclerosis, or with marked disorders of heart rhythm

DOSAGE: Follow the suggested manufacturers' guidelines. Most clinical studies used vinpocetine 5-10 mg 3 times daily orally or parenterally.